Type-2 Diabetes and Oxidative Stress

Free radicals are unstable molecules that can form in the body in response to stress, poor diet, infection, illness and many other factors. The presence of too many free radicals in the body creates a condition known as "oxidative stress." When this happens, an onslaught of oxidation reactions may begin to damage healthy tissue, often leading to premature aging and degenerative disease.

Chronic blood sugar imbalances, or dysglycemia, may both fuel and be fueled by oxidative stress. This can create a vicious, self-perpetuating cycle of metabolic imbalances. In response to faulty insulin and glucose metabolism, high levels of glucose in the blood or tissues may cause proteins to mutate, a process known as glycation, or glycosylation. This creates highly toxic by-products, called advanced glycosylation endproducts (AGEs).1 Structurally deformed proteins, AGEs are believed to mediate a vast range of degenerative conditions in the human body, from dementia and nerve damage to kidney dysfunction and skin wrinkling. Their potential to damage or destroy such a wide range of functions is not surprising when you consider that they generate 50 times more free radicals than non-glycated proteins.2 In excess, free radicals can also deform the normal structure of fat molecules. When this happens, fats become oxidized, creating a more reactive, destructive form of cholesterol that accelerates the build-up of plaque in the arteries. Such a process can accelerate the hardening and narrowing of blood vessels, a key pathological development in the most common type of heart disease, atherosclerosis.

To guard against these potentially devastating degenerative complications, it's important that both oxidative stress and glucose control be carefully kept in check and monitored regularly in patients with, or at risk of, type-2 diabetes.

The Oxidative Stress Analysis includes measurements of reduced glutathione, superoxide dismutase, gluthathione peroxidase, lipid peroxides, and hydroxyl radical markers as important indicators of antioxidant defense and oxidative stress in the body. Call to set up a nutritional consultation so that tests can be performed and a comprehensive strategy of lifestyle, dietary modification and nutrient supplementation can be implemented to aid you in reversing this disorder.


1 Munch G, Schinzel R, Loske C, Wong A, Durany N, Li JJ, Vlassara H, Smith MA, Perry G, Reiderer P. Alzheimer's disease - synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. J Neur Trans 1998;105:439-461.

2 Makita Z, Vlassara H, Rayfield E, Cartwright K, Friedman E, Rodby R, Cerami A, Bucala R. Hemoglobin-AGE: A circulating marker of advanced glycosylation. Science 1992;258:651-0653.

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Teresa Rispoli has her Ph.D. in Nutrition, is a licensed Acupuncturist and clinical researcher. She has been in practice for well over 25 years. It is through her clinical practice that she has gained insights into chronic health conditions.

If you are suffering from unexplained symptoms that come and go you owe it to yourself to find out why. Find out today call for a Nutritional Consultation with Dr. Rispoli.

Your happiness is a reflection of your health call today for an appointment, contact her office at (800) 956-7083 or (818) 707-3125.

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