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Thyroid Disorders and Depression

According to the Thyroid Society, a non-profit organization devoted to thyroid research, about 10%-15% of patients with depression have a thyroid hormone deficiency. Conversely, most patients with a thyroid deficiency, or hypothyroidism, show clinical signs of depression and may be treatment-resistant.1,2 In these cases imbalances of thyroxin (T4) and thyroid-stimulating hormone (TSH) may often be clearly detectable. In a subset of patients, however, particularly those with greater
treatment-resistance, mood symptoms may be closely linked with levels of triiodothyronine (T3), a more potent thyroid hormone contained in lesser quantities in the body.
3,4 Lower levels of T3 have been correlated with shorter time period between relapses of major depression.5

Measurement of thyroid antibodies can also provide important clinical information related to depression risk and treatment prognosis. Women with high levels of anti-thyroid peroxidase (anti-TPO) antibodies have been shown to be more vulnerable to depression.6 A recent German study concluded that "in cases of repeated depressive episodes, especially depression of the elderly and in nonresponders, it seems necessary not only to get lab [testing] for TSH, T3, and T4 but also to assess the autoimmune status of the thyroid gland (autoantibodies)."7

Postpartum thyroiditis is a chronic inflammation of the thyroid gland that may develop in as many as one out of ten women after giving birth. This condition can trigger symptoms of depression in conjunction with either hyperthyroidism or hypothryroidism. As many as one-third to one-half of women with high levels of thyroid antibodies in the first trimester of pregnancy develop this conditionÑand thus are subsequently at risk for developing post-partum depression.8

The Comprehensive Thyroid Assessment provides a thorough analysis of thyroid secretion and metabolism, including peripheral thyroid conversion and thyroid autoimmunity. By measuring hypersensitive thyroid-stimulating hormone (TSH), free serum thyroxine (fT4), free triiodothyroine (fT3), Reverse T3 (rT3), anti-thyroglobulin antibodies (anti-TG), and anti-thyroid peroxidase antibodies (anti-TPO), this test may provide important clinical clues for better treating patients with treatment-resistant depression.

References:
1 The Thyroid Society. Can depression be caused by thyroid disease? Available at:
http://the-thyroid-society.org/faq/33.html. Accessed December 28, 2000.
2 Hickie I, Bennett B, Mitchell P, Wilhelm K, Orlay W. Clinical and subclinical hypothyroidism inpatients with chronic and treatment-resistant depression. Aust N Z J Psychiatry 1996;30(2):246-52.
3 Rack SK, Makela EH. Hypothyroidism and depression: a therapeutic challenge. Ann Pharmacother
2000;34(10):1142-5.
4 Jackson IM. The thyroid axis and depression. Thyroid 1998;8(10):951-6.
5 Joffe RT, Marriott M. Thyroid hormone levels and recurrence of major depression. Am J Psychiatry
2000;157:1689-1691.
6 Pop VJ, Maartens LH, Leusink G, van Son MJ, Knottnerus AA, Ward AM, Metcalfe R, Weetman AP. Are atuoimmune thyroid dysfunction and depression related? J Clin Endocrinol Metab 1998;83(9):194-7.
7 Konig F, von Hippel C, Petersdorff T, Kaschka W. Thyroid autoantibodies in depressive disorders
[German]. Acta Med Austriaca 1999;26(4):126-98.
8 Stagnaro-Green A. Recognizing, understanding, and treating postpartum thyroiditis. Endocrinol Metab Clin North Am 2000;29(2):417-30,ix.


Call to set up a nutritional consultation so that tests can be performed and a comprehensive strategy of lifestyle, dietary modification and nutrient supplementation can be implemented to aid you in reversing this disorder.

Teresa Rispoli has her Ph.D. in Nutrition, is a licensed Acupuncturist and clinical researcher. She has been in practice for well over 25 years. It is through her clinical practice that she has gained insights into chronic health conditions. If you are suffering from unexplained symptoms that come and go you owe it to yourself to find out why. Find out today call for a Nutritional Consultation with Dr. Rispoli.

Your happiness is a reflection of your health call today For an appointment, contact her office at (800) 956-7083 or (818) 707-3125.

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Call 818-707-3126 to set up a Nutritional Consultation so that Dr. Rispoli can get to the root of your health concern, design a therapeutic diet and or comprehensive strategy of lifestyle changes, and nutritional support to aid you in the direction of wellness.

We also offer Functional Laboratory tests that can be done through the mail in the privacy of your home, to get to the root of your health concerns. Just choose lab tests and click on test of interest.

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Teresa Rispoli has her Ph.D. in Nutrition, is a licensed Acupuncturist, Master Herbalist, Certified Functional Nutritionist, has a Doctorate in Naturopathy and is a clinical researcher, and Licensed Esthetician. She has been in practice for well over 27 years. It is through her clinical practice that she has gained insights into chronic health conditions. If you are suffering from unexplained symptoms that come and go you owe it to yourself to find out why. Find out today call for a Nutritional Consultation with Dr. Rispoli.

If you are suffering from unexplained symptoms yourself to find out why. Find out today call for a Nutritional Consultation with Dr. Rispoli.

Remember that the body can heal itself if given the proper nutrients with the right environment and lifestyle.

Dr. Rispoli will help guide you to make the right choices for your individual needs. Teresa Rispoli will work with you to teach you which program is right for you so you can make informed decisions regarding your health.

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