MENU

 
IBD and Oxidative Stress

Increased activity of free radicals, the unstable molecules associated with cell damage, is theorized to underlie the mucosal injury commonly seen in inflammatory bowel disease (IBD). For this reason, decreased levels of circulating antioxidants have been found in patients with ulcerative colitis, and this deficiency has been strongly implicated in the pathophysiology of the disease.1 One study specifically found increased oxidized glutathione--which signals oxidative damage--associated with a clinical worsening of inflammation and general IBD status in patients.2

Another controlled study on children with Crohn's disease found clear evidence of oxidative stress as indicated by imbalances of glutathione peroxidase, glutathione and other crucial oxidative stress markers.3 Moreover, because inflamed intestinal mucosa is associated with decreased levels of superoxide disumutase in adults with Crohn's disease, researchers postulate that these metabolic imbalances may also make them more susceptible to intestinal damage generated by free radicals.4

Many antioxidant molecules rely on nutrients such as manganese, copper, zinc and selenium for their formation; for this reason, element imbalances can also play an important role in influencing the status of free radicals in the body 5,6 (see IBD & Elemental Analysis).

The Oxidative Stress Analysis (urine) identifies markers of hydroxyl radical activity following a challenge dose of aspirin and acetaminophen. The blood profile includes assays of reduced whole blood glutathione, glutathione peroxidase and superoxide dismutase.

References:
1 Ramakrishna BS, Varghese R, Jayakumar S, Mathan M, Balasubramanian KA. Circulating antioxidants in ulcerative colitis and their relationship to disease severity and activity. J Gastroenterol Hepatol 1997;12(7):490-494.
2 Holmes EW, Yong SL, Eiznhamer D, Keshavarzian A. Glutathione content of colonic mucosa: evidence for oxidative damage in active ulcerative colitis. Dig Dis Sci 1998;43(5):1088-1095.
3 Hoffenberg EJ, Deutsch J, Smith S, Sokol RJ. Circulating antioxidant concentrations in children with inflammatory bowel disease. Am J Clin Nutr 1997;65(5):1482-1488.
4 Mulder TP, Verspaget HW, Janssens AT, de Bruin PA, Pena AS, Lamers CB. Decrease in two intestinal copper/zinc containing proteins with antioxidant function in inflammatory bowel disease. Gut 1991;32(10):1146-1150.
5 Royall D, Jeejeebhoy KN, Baker JP, Allard JP, Habal FM, Cunnane SC, Greenberg GR. Comparison of amino acid vs. peptide based on enteral diets in active Crohn's disease: clinical and nutritional outcome. Gut 1994;35(60:783-787).
6 Struniolo GC, Mestriner C, Lecis PE, D'Odorico A, Venturi C, Irato P, et. Al. Altered plasma and mucosal concentrations of trace elements and antioxidants in active ulcerative colitis. Scand J. Gastroeneterol 1998;33(60:644-649).


Call to set up a nutritional consultation so that tests can be performed and a comprehensive strategy of lifestyle, dietary modification and nutrient supplementation can be implemented to aid you in reversing this disorder.

Teresa Rispoli has her Ph.D. in Nutrition, is a licensed Acupuncturist and clinical researcher. She has been in practice for well over 25 years. It is through her clinical practice that she has gained insights into chronic health conditions. If you are suffering from unexplained symptoms that come and go you owe it to yourself to find out why. Find out today call for a Nutritional Consultation with Dr. Rispoli.

Your happiness is a reflection of your health call today For an appointment, contact her office at (800) 956-7083 or (818) 707-3125.

We also offer Functional Laboratory tests that can be done through the mail in the privacy of your home to help determine why you are having these symptoms. For more information on these click on lab tests.

The information herein is not intended as diagnosis, treatment or a cure. Should you have a medical condition please seek the advice of your medical doctor.

****************


Call 818-707-3126 to set up a Nutritional Consultation so that Dr. Rispoli can get to the root of your health concern, design a therapeutic diet and or comprehensive strategy of lifestyle changes, and nutritional support to aid you in the direction of wellness.

We also offer Functional Laboratory tests that can be done through the mail in the privacy of your home, to get to the root of your health concerns. Just choose lab tests and click on test of interest.

Click on Related Articles or Products to the left for more information.

Teresa Rispoli has her Ph.D. in Nutrition, is a licensed Acupuncturist, Master Herbalist, Certified Functional Nutritionist, has a Doctorate in Naturopathy and is a clinical researcher, and Licensed Esthetician. She has been in practice for well over 27 years. It is through her clinical practice that she has gained insights into chronic health conditions. If you are suffering from unexplained symptoms that come and go you owe it to yourself to find out why. Find out today call for a Nutritional Consultation with Dr. Rispoli.

If you are suffering from unexplained symptoms yourself to find out why. Find out today call for a Nutritional Consultation with Dr. Rispoli.

Remember that the body can heal itself if given the proper nutrients with the right environment and lifestyle.

Dr. Rispoli will help guide you to make the right choices for your individual needs. Teresa Rispoli will work with you to teach you which program is right for you so you can make informed decisions regarding your health.

She is the founder and Director for Complete Health. She will find the root of your health issues, from a Functional Health perspective, and personalize a health building program to help you experience vibrant health.

Schedule your Wellness Consultation TODAY with Dr. Rispoli

Call 818-707-3126.

Yours For Inner Health and Outer Beauty,
Teresa Rispoli, DCN, CFN, LAC.

If you'd like to receive your own Complete Health E Newsletter, please sign up on our website: www.completehealthinstitute.com

We have a strict anti-spam policy. We know how important your privacy is to you. That's why we do not share your email address with anyone. Click here to read our Privacy Policy

To Contact Us:
Complete Health
28247 Agoura Rd
Agoura Hills, CA 91301
818-707-3126
support@completehealthinstitute.com

To unsubscribe from future mailings, reply with "unsubscribe".

Let us know if you like this article.