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IBD and Intestinal Permeability

(Leaky Gut)

The integrity of the gut mucosal layer is crucial for the body to prevent bacteria, antigens, and undigested food proteins from seeping through the GI barrier and into the systemic circulation. Increased permeability, then, can result in a chronically over reactive immune system in constant battle with toxins and allergens normally kept at bay.

Many scientists believe that increased intestinal permeability is the critical dysfunctional mechanism that sets inflammatory bowel disease (IBD) into motion and modulates subsequent progression of the disease. Relatives of Crohn's disease patients, who have a greater likelihood of developing the disease, have been shown to exhibit a higher degree of intestinal permeability.1 Thus, testing for intestinal permeability (IP) can help determine individuals at high risk for developing the disease--individuals whose systems may be more sensitive to various environmental triggers.2 IP testing has also been recommended for early diagnosis of IBD in children--who often go undiagnosed in the early stages of the disease because of non-specific symptoms.3

Because the condition known as "leaky gut" is so inextricably interlinked with the pathogenesis of IBD, particularly intestinal inflammation, intestinal permeability serves as an important indicator of upper bowel involvement in the disease.4 In general, numerous investigators have supported the usefulness of measuring intestinal permeability for gauging potential remission and relapses of IBD, and monitoring the general efficacy of treatment.5-7

The Intestinal Permeability Assessment is a non-invasive assessment that measures urinary clearance of two non-metabolized sugar molecules, lactulose and mannitol, to assess increased intestinal permeability and malabsorption. This assessment is a critical tool in the diagnosis, monitoring, and treatment of IBD.

References:
1 May GR, Sutherland LR, Meddings JB. Is small intestinal permeability really increased in relatives of patients with Crohn's disease? Gastroenterology 1993;104:1627-32.
2 Meddings JB. Review article: intestinal permeability in Crohn' disease. Aliment Pharmacol Ther 1997;11 Suppl 3:47-53.
3 Murphy MS, Easham EJ, Nelson R, Pearson AD, Laker MF. Intestinal permeability in Crohn's disease. Arch Dis Child 1989;64(3):321-325.
4 Wyatt J, Oberhuber G, Pongratz S, Puspok A, Moser G, Novacek G, Lochs H, Vogelsang H. Increased gastic and intestinal permeability in patients with Crohn's disease. Am J Gastroenterol 1997;92(10):1891-1896.
5 Franchimont D, Louis E, Simon S, Belaiche J. Intestinal permeability in Crohn's disease. Am J Gastroenterol Belg 1996;59(1):15-19.
6 Wyatt J, Vogelsang H, Hubl W, Waldhoer T, Lochs H. Intestinal permeability and the prediction of relapse in Crohn's disease.
7 MA T. Intestinal epithelial barrier dysfunction in Crohn's disease. Proc Soc Exp Biol Med 1997;214(4):318-327.


Call to set up a nutritional consultation so that tests can be performed and a comprehensive strategy of lifestyle, dietary modification and nutrient supplementation can be implemented to aid you in reversing this disorder.

Teresa Rispoli has her Ph.D. in Nutrition, is a licensed Acupuncturist and clinical researcher. She has been in practice for well over 25 years. It is through her clinical practice that she has gained insights into chronic health conditions. If you are suffering from unexplained symptoms that come and go you owe it to yourself to find out why. Find out today call for a Nutritional Consultation with Dr. Rispoli.

Your happiness is a reflection of your health call today For an appointment, contact her office at (800) 956-7083 or (818) 707-3125.

We also offer Functional Laboratory tests that can be done through the mail in the privacy of your home to help determine why you are having these symptoms. For more information on these click on lab tests.

The information herein is not intended as diagnosis, treatment or a cure. Should you have a medical condition please seek the advice of your medical doctor.

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Call 818-707-3126 to set up a Nutritional Consultation so that Dr. Rispoli can get to the root of your health concern, design a therapeutic diet and or comprehensive strategy of lifestyle changes, and nutritional support to aid you in the direction of wellness.

We also offer Functional Laboratory tests that can be done through the mail in the privacy of your home, to get to the root of your health concerns. Just choose lab tests and click on test of interest.

Click on Related Articles or Products to the left for more information.

Teresa Rispoli has her Ph.D. in Nutrition, is a licensed Acupuncturist, Master Herbalist, Certified Functional Nutritionist, has a Doctorate in Naturopathy and is a clinical researcher, and Licensed Esthetician. She has been in practice for well over 27 years. It is through her clinical practice that she has gained insights into chronic health conditions. If you are suffering from unexplained symptoms that come and go you owe it to yourself to find out why. Find out today call for a Nutritional Consultation with Dr. Rispoli.

If you are suffering from unexplained symptoms yourself to find out why. Find out today call for a Nutritional Consultation with Dr. Rispoli.

Remember that the body can heal itself if given the proper nutrients with the right environment and lifestyle.

Dr. Rispoli will help guide you to make the right choices for your individual needs. Teresa Rispoli will work with you to teach you which program is right for you so you can make informed decisions regarding your health.

She is the founder and Director for Complete Health. She will find the root of your health issues, from a Functional Health perspective, and personalize a health building program to help you experience vibrant health.

Schedule your Wellness Consultation TODAY with Dr. Rispoli

Call 818-707-3126.

Yours For Inner Health and Outer Beauty,
Teresa Rispoli, DCN, CFN, LAC.

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