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IBD and Amino Acids

Three amino acids are critical to antioxidant, anti-inflammatory functions: cysteine, glutathione, and taurine. Because these amino acids modulate the inflammatory response, evaluating their levels can be critical for managing the tissue inflammation that occurs in conjunction with inflammatory bowel disease.

Cysteine influences the synthesis of the antioxidant glutathione (GSH), which is thought to play an important role in the inflammatory response by influencing the production of phagocytes. A recent study by German researchers at the University of Heidelberg found reduced mucosal glutathione synthesis in patients with inflammatory bowel disease, due to enzyme deficiencies and decreased levels of cyst(e)ine.1

Taurine acts as a specific scavenger for the hypochlorite ion, and adequate levels naturally limit the degree of inflammation.2 When taurine is low, the inflammatory response is enhanced, commonly resulting in oxidative stress reactions.

In addition, recent research has noted abnormally low plasma cystine and glutamine levels as occurring as part of a multi factorial metabolic dysequilibrium often seen in Crohn's disease, ulcerative colitis, chronic fatigue syndrome, AIDS, and many other diseases.3 It may be for this reason that amino acid-enriched diets often seem to markedly improve clinical symptoms of IBD.4,5

Crohn's disease patients have also been found to exhibit elevated levels of homocysteine,6 signaling possible dysfunctions within vitamin B12 metabolic pathways, as well as an increased risk of cardiovascular disease.

Amino Acids Analysis is a comprehensive and sensitive analysis for urine or plasma analytes that can provide important information about nutrient cofactor status and inflammation, which is crucial for a full understanding of metabolic mechanisms involved in disorders such as IBD.

References:
1 Sido B, Hack V, Hochlehnert A, Lipps H, Herfarth C, Droge W. Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Gut 1998;42(4):485-492.
2 Son M, Ko JI, Kim WB, Kang HK, Kim BK. Taurine can ameliorate inflammatory bowel disease in rats. Adv Exp Med Biol 1998;442:291-298.
3 Droge W, Holm E. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J 1997;11(13):1077-1089.
4 Fujita T, Sakurai K. Efficacy of glutamine-enriched enteral nutrition in an experimental model of mucosal ulcerative colitis. Br J Surg 1995;82(6):749-751.
5 Royall D, Jeejeebhoy KN, Baker JP, Allard JP, Habal FM, Cunnane SC, Greenberg GR. Comparison of amino acid v peptide based enteral diets in active Crohn's disease: clinical and nutritional outcome. Gut 1994;35(6):783-787.
6 Lambert D, Benhayoun S, Adjalla C, Gelot MA, Renkes P, Felden F, et. al. Crohn's disease and vitamin B12 metabolism. Dig Dis Sci 1996;41(7):1417-1422.


Call to set up a nutritional consultation so that tests can be performed and a comprehensive strategy of lifestyle, dietary modification and nutrient supplementation can be implemented to aid you in reversing this disorder.

Teresa Rispoli has her Ph.D. in Nutrition, is a licensed Acupuncturist and clinical researcher. She has been in practice for well over 25 years. It is through her clinical practice that she has gained insights into chronic health conditions. If you are suffering from unexplained symptoms that come and go you owe it to yourself to find out why. Find out today call for a Nutritional Consultation with Dr. Rispoli.

Your happiness is a reflection of your health call today For an appointment, contact her office at (800) 956-7083 or (818) 707-3125.

We also offer Functional Laboratory tests that can be done through the mail in the privacy of your home to help determine why you are having these symptoms. For more information on these click on lab tests.

The information herein is not intended as diagnosis, treatment or a cure. Should you have a medical condition please seek the advice of your medical doctor.

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Call 818-707-3126 to set up a Nutritional Consultation so that Dr. Rispoli can get to the root of your health concern, design a therapeutic diet and or comprehensive strategy of lifestyle changes, and nutritional support to aid you in the direction of wellness.

We also offer Functional Laboratory tests that can be done through the mail in the privacy of your home, to get to the root of your health concerns. Just choose lab tests and click on test of interest.

Click on Related Articles or Products to the left for more information.

Teresa Rispoli has her Ph.D. in Nutrition, is a licensed Acupuncturist, Master Herbalist, Certified Functional Nutritionist, has a Doctorate in Naturopathy and is a clinical researcher, and Licensed Esthetician. She has been in practice for well over 27 years. It is through her clinical practice that she has gained insights into chronic health conditions. If you are suffering from unexplained symptoms that come and go you owe it to yourself to find out why. Find out today call for a Nutritional Consultation with Dr. Rispoli.

If you are suffering from unexplained symptoms yourself to find out why. Find out today call for a Nutritional Consultation with Dr. Rispoli.

Remember that the body can heal itself if given the proper nutrients with the right environment and lifestyle.

Dr. Rispoli will help guide you to make the right choices for your individual needs. Teresa Rispoli will work with you to teach you which program is right for you so you can make informed decisions regarding your health.

She is the founder and Director for Complete Health. She will find the root of your health issues, from a Functional Health perspective, and personalize a health building program to help you experience vibrant health.

Schedule your Wellness Consultation TODAY with Dr. Rispoli

Call 818-707-3126.

Yours For Inner Health and Outer Beauty,
Teresa Rispoli, DCN, CFN, LAC.

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