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Osteoporosis and Adrenal Hormones

High levels of cortisol, caused either by the body's overproduction or by chronic administration of cortisone, are well-established causes of osteoporosis.1,2 Increased cortisol levels have been associated with calcium malabsorption, as well as osteoporosis in oophorectomized women.3 Higher cortisol levels in athletes with exercise-related amenorrhea have also been correlated with significantly lower bone mineral density.4

Although testosterone and dehydroepiandrosterone (DHEA) are considered male hormones, they are produced in substantial amounts by the ovaries. Each of these hormones has been shown to enhance new bone formation. Serum levels of DHEA tend to decline around the time of menopause. A further fall in levels occurs around age 70, as the adrenal gland loses its capacity to produce the hormone. Maintaining optimal levels of DHEA may help to prevent or reverse osteoporosis.

The Adrenocortex Stress Profile provides a circadian analysis of cortisol, along with a measurement of DHEA, to reveal how imbalances of adrenal hormones may be playing a contributing factor in bone loss.

References:
1 Bockman RS, Weinerman SA. Steroid-induced osteoporosis. Orthop Clin North Am 1990;21(1):97-107.
2 Catargi B, Tabarin A, Basse-Cathalinat B, Ducassou D, Roger P. Development of bone mineral density after cure of CushingÕs syndrome. Ann Endocrinol 1996;57(3):203-208.
3 Manolagas SC, Anderson DC, Lindsay R. Adrenal steroids and the development of osteoporosis in oophorectomized women. Lancet 1979;2:597.
4 Ding JH, Sheckter CB, Drinkwater BL, Soules MR, Bremner WJ. High serum cortisol levels in exercise-associated amenorrhea. Ann Int Med 1988;108:530-534.

All lab tests can be done through the mail in the privacy of your own home, except blood tests, we send you to a lab to have your blood drawn for these. After you pay for the test we mail you the kit, the results take two weeks, the test results will be mailed to us and we will call you to go over the results, its that easy! All tests include the consultation for the report of findings.

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