Oxidative damage is caused by free radicals-unstable and potentially damaging cells in the body linked to premature aging, illness, and disease. HIV patients are often under chronic oxidative stress.1 This heightened free radical activity is associated with the progressive development of AIDS and, specifically, the viral replication, inflammatory response, immune dysfunction, weight loss, and increased sensitivity to drug toxicities that attend the disease.2

Glutathione and glutathione peroxidase levels are extremely crucial in AIDS/HIV. These important molecules guard against oxidative stress, and can help suppress the development of viruses.3 Studies show that glutathione and glutathione peroxidase are much lower in symptomatic AIDS patients than in HIV patients without symptoms or in healthy subjects.4,5 A recent study on AIDS wasting syndrome noted that decreasing oxidative stress is a crucial component of a therapeutic protocol for HIV-infected individuals.6

The Oxidative Stress Profile evaluates the body's oxidative stress and antioxidant potential using glutathione markers, as well as free radical, hydroxyl radical, and lipid markers. It provides valuable insight into oxidative damage associated with AIDS symptoms.

References:
1 Repetto M, Reides C, Gomez Carretero ML, Costa M, Griemberg G, Llesuy S. Clin Chim Acta 1996;255(2):107-117.
2 Pace GW, Leaf CD. The role of oxidative stress in HIV disease. Free Radic Biol Med 1995;19(4):523-528.
3 Hori K, Hatfield D, Maldarelli F, Lee BJ, Clouse KA. Selenium supplementation suppresses tumor necrosis factor alpha-induced human immunodeficiency virus type 1 replication in vitro. AIDS Res Hum Retroviruses 1997; 13(15):1325-1332.
4 Akerlund B, Tynell E, Bratt G, Bielenstein M, Lidman C. N-acetylecysteine treatment and the risk of toxic reactions to trimethoprim-supamethoxazole in primary Pneumocytis carinii prophylaxis in HIV-infected patients. J Infect 1997;35(2):143-147.
5 Look MP, Rockstroh JK, Rao GS, Kreuzer KA, Barton S, Lemoch H, et. al. Serum selenium, plasma glutathione (GSH) and erythrocyte glutathione peroxidase (GSH-Px)-levels in asymptomatic versus symptomatic human immunodeficiency virus-1 (HIV-1)-infection. Eur J Clin Nutr 1997;51(4):266 272.
6 Kaminski M, Weil S, Bland J, Jan P. AIDS wasting syndrome as an entero-metabolic disorder: the gut hypothesis. Alt Med Rev 1998 (3): 40-53.


All lab tests can be done through the mail in the privacy of your own home, except blood tests, we send you to a lab to have your blood drawn for these. After you pay for the test we mail you the kit, the results take two weeks, the test results will be mailed to us and we will call you to go over the results, its that easy! All tests include the consultation for the report of findings.

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