Healthy metabolism of essential fatty acids is crucial for proper functioning of eicosanoids, hormone-like substances which mediate the body's inflammatory response. Because eicosanoids are involved in the inflammatory skin reactions commonly seen in dermatitis and psoriasis, researchers believe that they may hold the key for successful treatment of many skin disorders.1,2

Numerous studies have revealed clinical imbalances of specific essential fatty acids associated with a variety of skin problems. A common pattern of fatty acid imbalance seen in atopic eczema is elevated linoleic acid, accompanied by low levels of its highly unsaturated metabolites dihomogamma linolenic and arachidonic acid.3,4 These metabolites are formed through the action of a crucial enzyme--delta-6-desaturase--and disruption of this enzyme's normal function is theorized to trigger important changes in both the skin's barrier function and inflammatory response.5-7 Hence dry, itchy, scaly skin is a hallmark sign of fatty acid deficiency.

Clinical case-controlled studies investigating the use of fatty acid therapy in skin disorders have shown promising results. Different types of fatty acid therapy have been associated with clinical improvement in atopic dermatitis, seborrhea, and eczema, with clinical scores linked directly to a rise in the levels of specific fatty acids.8-12 Many practitioners also use fatty acid therapy as a powerful means of improving skin condition in patients with no overt skin disorders.

Great Smokies' Essential and Metabolic Fatty Acids Analysis is a sensitive, detailed, and comprehensive analysis that can reveal specific fatty acid imbalances, allowing for precisely targeted intervention and careful monitoring of therapy.

References:
1 Berbis P, Hesse S, Privat Y. Essential fatty acids and the skin [French]. Allerg Immunol 1990;22(6):225-231.
2 Ruzicka T. The physiology and pathophysiology of eicosanoids in the skin. Eicosanoids 1988;1(2):59-72.
3 Lindskov R, Holmer G. Polyunsaturated fatty acids in plasma, red blood cells and mononuclear cell phospholipids of patients with atopic dermatitis. Allergy 1992;47(5):517-521.
4 Wright S, Sanders TZ. Adipose tissue essential fatty acid composition in patients with atopic eczema. Eur J Clin Nutr 1991;45(10):510-505.
5 Horrobin DF. Fatty acid metabolism in health and disease: the role of delta-6-desaturase. Am J Clin Nutr 1993;57(5 Suppl):732S-736S.
6 Willemaers V, Stas I, Pierard-Franchimont C, Cornil F, Pierard GE. Atopic dermatitis [French]. Rev Med Liege 1998;53(2):67-70.
7 Melnik B, Plewig G. Are disturbances of omega-6-fatty acid metabolism involved in the pathogenesis of atopic dermatitis? Acta Derm Venereol Suppl 1992;176:77-85.
8 Biagi PL, Bordoni A, Hrelia S, Celadon M, Ricci GP, Cannella V, Patrizi A, et. al. The effect of gamma-linolenic acid on clinical status, red cell fatty acid composition and membrane microviscosity in infants with atopic dermatitis. Drugs Exp Clin Res 1994;20(2):77-84.
9 Tollesson A, Frithz A, Berg A, Kalrman G. Essential fatty acids in infantile seborrheic dermatitis. J Am Acad Dermatol 1993;28(6):957-961.
10 Andreassi M, Forleo P, Di Lorio Z, Masci S, Abate G, Amerio P. Efficacy of gamma-linolenic acid in the treatment of patients with atopic dermatitis. J Int Med Res 1997;25(5):266-274.
11 Schalin-Karrila M, Mattila L, Jansen CT, Uotila P. Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. Br J Dermatol 1987;117(1):11-19.
12 Morse PF, Horrobin DF, Manku MS, Stewart JC, Allen R, et. al. Meta-analysis of placebo-controlled studis of the efficacy of Epogam in the treatment of atopic eczema. Relationship between plasma essential fatty acid changes and clinical response. Br J Dermatol 1989;121(1):75-90.

Call to set up a nutritional consultation so that tests can be performed and a comprehensive strategy of lifestyle, dietary modification and nutrient supplementation can be implemented to aid you in reversing this disorder.

For an appointment, contact our office at: 800-956-7083 and visit our web site www.completehealthinstitute.com go to lab tests and click on appropriate test for information.

Dr. Rispoli, Ph.D., L Ac. has had a clinical practice for over 20 years. Her programs work because she is so thorough in testing and providing a nutritional approach. Remember that the body can heal itself if given the proper nutrients.

The information herein is not intended as diagnosis, treatment or a cure. Should you have a medical condition please seek the advice of your medical doctor.