For years, researchers have looked for biochemical methods to determine bone loss rates associated with the development of osteoporosis.1 The Bone Resorption Assessment focuses on two collagen crosslinks with greater specificity for bone resorption, pyridinium (Pyd) and deoxypyridinium (D-Pyd).

Research supports the use of Pyd and D-Pyd as excellent, sensitive and specific indicators of bone loss due to osteoporosis.2,3 Presence in the urine of higher than normal amounts of Pyd and D-Pyd indicate a rapid rate of bone loss.4-6 A high rate of bone turnover in an untreated postmenopausal woman indicates that bone loss is likely to be rapid. Nearly all women will show high bone turnover in the first few years after menopause, but about a third will continue to have high turnover 10-20 years after menopause. Many clinicians believe such women are destined to suffer extensive bone loss and should be targeted for aggressive therapy to block bone resorption.7

Many studies have investigated the relationship of pyridinium markers to osteoporosis. In one, the urinary excretion of Pyd crosslinks was evaluated in a group of elderly women with untreated osteoporosis.5 The crosslinks relative to creatinine correlated closely with bone resorption with osteocalcin, a specific marker of bone formation and osteoporosis.

In another study, elderly women with femoral fractures associated with osteoporosis were compared with age-matched controls.6 Women with fractures and osteoporosis excreted higher levels of crosslinks. Patients with recent fractures showed higher excretion of both markers than those without recent fractures, indicating that accidental bone fractures also increase crosslink excretion.

Although exercise is an important element in guarding against bone loss, many physicians are noticing an increase in the early onset of bone loss in premenopausal women who exercise vigorously while maintaining extremely lowfat diets. I have personally researched and taken the product Pro Bono which I find to be an amazing comprehensive formulation for preventing and reversing osteoporosis. Its the only comprehensive product that addresses both the prevention of bone loss, and stimulation of bone growth, all in convenient, easy A.M. & P.M. pre packs.

Strontium, one of the key ingredients in Pro Bono actually works better than calcium for preventing bone loss and replacing the old bone with strong new bone growth. Researchers reporting in the New England Journal of Medicine found a 41% reduction in vertebral fractures over 3 years when adding strontium to a stable calcium and vitamin D diet regimen. While calcium is important, calcium uptake is severely limited when taken as a single ingredient supplement. Pro Bono provides multiple ingredient sources strong bone growth, and a therapeutically dosed 1000 mg of strontium.

The Bone Resorption Assessment is a simple, direct urinary assay of pyridinium and deoxypyridinium crosslinks, useful in identifying early onset of rapid bone loss, allowing for timely intervention and effective monitoring of bone support therapies.

References:
1 Azria M. Calcif Tissue Int.1989;45:7-11.
2 Hassager C et al. Clin Endocrinology 1992;37:45-50.
3 Delmas PD. Bone 1992;13:S17-21.
4 Uebelhart D et al. Bone Miner 1990; 8:87-96.
5 Delmas PD et al. J Bone Min Res 1991;6(6):639-44.
6 McLaren AM et al. Ann Rheum Dis 1992;51:648-51.
7 Ettinger B. Current Opinion OB GYN 1993;5:396-403.

Call to set up a nutritional consultation so that tests can be performed and a comprehensive strategy of lifestyle, dietary modification and nutrient supplementation can be implemented to aid you in reversing this disorder.

For an appointment, contact our office at: 800-956-7083 and visit our web site www.completehealthinstitute.com go to lab tests and click on appropriate test for information.

Dr. Rispoli, Ph.D., L Ac. has had a clinical practice for over 20 years. Her programs work because she is so thorough in testing and providing a nutritional approach. Remember that the body can heal itself if given the proper nutrients.

The information herein is not intended as diagnosis, treatment or a cure. Should you have a medical condition please seek the advice of your medical doctor.