animal studies have shown that the adrenal hormone DHEA and its
sulfate form, DHEA-S, protect the brain from neuronal damage and
enhance memory function.1-3 In
humans, low DHEA-S correlates with the
presence of organic brain syndrome in
elderly men, and with Alzheimer's disease
in both men and women.4-5 Although
a recent study found that DHEA replacement
did not influence cognitive performance
in a group of healthy elderly individuals,6 this
may be because DHEA-S affects brain function
through its balancing effect on the adrenal
is released in response to stress,
and over secretion of this powerful
hormone can impair memory function,
even in healthy adults.7 For
this reason, researchers believe
that changes in cortisol responses
caused by acute or chronic stress
could be a contributing factor underlying
the loss of memory associated with
with chronically high levels of cortisol
show accelerated degeneration of
the hippocampus, a region of the
brain for proper cognitive function
and emotional well-being.9
on the other hand, because it functions as an anti-glucocorticoid,
can block some of the effects of cortisol in the processes that
mediate learning and memory.10
Stress Profile provides a complete 24-hour circadian
analysis of cortisol and an assay of DHEA-S, revealing imbalances
of adrenal hormones that could be playing an important role in preserving
the integrity of memory function.
1 Flood JF, Roberts E. Dehydroepiandrosterone sulfate improves memory
in aging mice. Brain Res 1988 448(1):178-181.
2 Melchior CL, Ritzmann RF. Neurosteroids block the memory-impairing
effects of ethanol in mice.
3 Roberts, E, Bologa L, Flood JF, Smith GE. Effects of dehydroepiandrosterone
and its sulfate on brain tissue in culture and on memory in mice.
Brain Res 1987 406(1-2):357-362.
4 Rudman D, Shetty KR, Mattson DE. Plasma dehydropepiandrosterone
sulfate in nursing home men. J Am Geriatr Soc 1990;38(4):421-427.
5 Nasman B, Olsson T, Backstron T, Eriksson S, Grankvist K, Viitanen
M, Bucht G. Serum dehydroepiandrosterone sulfate in Alzheimer's
disease and in multi-infarct dementia. Biol Psychiatry 1991;30(7):684-690.
6 Wolf OT, Neumann O, Hellhammer DH, Geiben AC, Strasburger CJ,
Dressendorfer RA, et. al. J Clin Endocrinol Metab 1997;82(7):2363-2367.
7 Kirschbaum C, Wolf OT, May M, Wippich W, Hellhammer DH. Stress-
and treatment-induced elevations of cortisol levels associated with
impaired declarative memory in healthy adults. Life Sci 1996;58(17):1475-1483.
8 Lupien SJ, Gaudreau S, Tchiteya BM, Maheu F, Sharma S, Naier NP,
et. al. Stress-induced declarative memory impairment in healthy
elderly subjects: relationship to cortisol reactivity. J Clin Endocrinol
9 Sapolsky RM. Why stress is bad for your brain. Science 1996;273:749-750.
10 Fleshner M, Pugh CR, Tremblay D, Rudy JW. DHEA-S selectively
impairs contextual-fear conditioning: support for the antiglucocorticoid
hypothesis. Behav Neurosci 1997;111(3):512-517.
to set up a nutritional consultation so that tests can be performed
and a comprehensive strategy of lifestyle, dietary modification
and nutrient supplementation can be implemented to aid you in reversing
Rispoli has her Ph.D. in Nutrition,
is a licensed Acupuncturist and
clinical researcher. She has been
in practice for well over 25 years.
It is through her clinical practice
that she has gained insights into
chronic health conditions. If
you are suffering from unexplained
symptoms that come and go you owe
it to yourself to find out why.
Find out today call for a Nutritional
Consultation with Dr. Rispoli.
happiness is a reflection of
your health call today For
an appointment, contact her office
at (800) 956-7083 or (818) 707-3125.
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tests that can be done through
the mail in the privacy of your
home to help determine why you
are having these symptoms. For
more information on these click
on lab tests.
The information herein is not intended
as diagnosis, treatment or a cure.
Should you have a medical condition
please seek the advice of your medical