Melatonin,
a hormone produced by the pineal gland in the brain, is secreted
in a cyclical pattern in response to the light-dark cycle. Bright
light during the day inhibits melatonin release, while darkness
stimulates increased production and induces sleep. Variations in
melatonin levels are closely linked with seasonal reproductive function
in animals. Increasing darkness during the winter months triggers
higher levels of melatonin, which are believed to play a role in
inhibiting fertility.
Although
humans do not display such a dramatic seasonal variation in fertility,
melatonin levels are nevertheless postulated to exert a potentially
significant influence on sperm production in men. One study found
that compared to healthy controls, men with low sperm counts or
the inability to produce sperm have significantly higher levels
of melatonin. Researchers postulated that these high concentrations
of melatonin may either be a secondary reaction to other hormone
imbalances in the infertile men, or may be a primary mechanism that
wears away the lining of sperm-carrying tubules in the testes.1
Another
study of men with reduced ability to produce sperm found that melatonin
levels were higher in their semen samples and were associated with
decreased sperm progression.2 In
a recent article entitled "Melatonin-dependent
infertility",a Finnish researcher
suggests that melatonin may play an
essential role in sperm formation,
and that bright light therapy to suppress
melatonin concentration may be a helpful
treatment for infertile males and females
who exhibit melatonin imbalances.3
The
Comprehensive Melatonin Profile evaluates melatonin activity
over the complete light-dark cycle, providing a circadian analysis
that can uncover imbalances linked to male infertility.
References
1 Karasek
M, Pawlikowski M, Nowlakowska-Jankiewicz B, Kolodziej-Maciejewska
H, Zieleniewski J, Cieslak D, Leidenberger F. Circadian variations
in plasma melatonin, FSH, LH, and prolactin and testosterone levels
in infertile men. Pineal Res 1990;9(2):149-57.
2 Yie
SM, Daya S, Brown GM, Deys L, YoungLai EV. Melatonin and aromatase
stimulating activity of human seminal plasma. Andrologia 1991 May-Jun;23(3):227-31.
3 Partonen
T. Melatonin-dependent infertility. Med Hypotheses 1999 Mar;52(3):269-7.
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The information herein is not intended
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Should you have a medical condition
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The information herein is not intended
as diagnosis, treatment or a cure.
Should you have a medical condition
please seek the advice of your medical
doctor. |