(Leaky Gut)

The integrity of the gut mucosal layer is crucial for the body to prevent bacteria, antigens, and undigested food proteins from seeping through the GI barrier and into the systemic circulation. Increased permeability, then, can result in a chronically overreactive immune system in constant battle with toxins and allergens normally kept at bay.

Many scientists believe that increased intestinal permeability is the critical dysfunctional mechanism that sets inflammatory bowel disease (IBD) into motion and modulates subsequent progression of the disease. Relatives of Crohn's disease patients, who have a greater likelihood of developing the disease, have been shown to exhibit a higher degree of intestinal permeability.1 Thus, testing for intestinal permeability (IP) can help determine individuals at high risk for developing the disease--individuals whose systems may be more sensitive to various environmental triggers.2 IP testing has also been recommended for early diagnosis of IBD in children--who often go undiagnosed in the early stages of the disease because of non-specific symptoms.3

Because the condition known as "leaky gut" is so inextricably interlinked with the pathogenesis of IBD, particularly intestinal inflammation, intestinal permeability serves as an important indicator of upper bowel involvement in the disease.4 In general, numerous investigators have supported the usefulness of measuring intestinal permeability for gauging potential remission and relapses of IBD, and monitoring the general efficacy of treatment.5-7

The Intestinal Permeability Assessment is a non-invasive assessment that measures urinary clearance of two non-metabolized sugar molecules, lactulose and mannitol, to assess increased intestinal permeability and malabsorption. This assessment is a critical tool in the diagnosis, monitoring, and treatment of IBD.

References:
1 May GR, Sutherland LR, Meddings JB. Is small intestinal permeability really increased in relatives of patients with Crohn's disease? Gastroenterology 1993;104:1627-32.
2 Meddings JB. Review article: intestinal permeability in Crohn' disease. Aliment Pharmacol Ther 1997;11 Suppl 3:47-53.
3 Murphy MS, Easham EJ, Nelson R, Pearson AD, Laker MF. Intestinal permeability in Crohn's disease. Arch Dis Child 1989;64(3):321-325.
4 Wyatt J, Oberhuber G, Pongratz S, Puspok A, Moser G, Novacek G, Lochs H, Vogelsang H. Increased gastic and intestinal permeability in patients with Crohn's disease. Am J Gastroenterol 1997;92(10):1891-1896.
5 Franchimont D, Louis E, Simon S, Belaiche J. Intestinal permeability in Crohn's disease. Am J Gastroenterol Belg 1996;59(1):15-19.
6 Wyatt J, Vogelsang H, Hubl W, Waldhoer T, Lochs H. Intestinal permeability and the prediction of relapse in Crohn's disease.
7 MA T. Intestinal epithelial barrier dysfunction in Crohn's disease. Proc Soc Exp Biol Med 1997;214(4):318-327.

Call to set up a nutritional consultation so that tests can be performed and a comprehensive strategy of lifestyle, dietary modification and nutrient supplementation can be implemented to aid you in reversing this disorder.

For an appointment, contact our office at: 800-956-7083 or 818 707-3126.

Dr. Rispoli, Ph.D., L.Ac. has had a clinical practice for over 20 years. Her programs work because she is so thorough in testing and providing a nutritional approach. Remember that the body can heal itself if given the proper nutrients.

The information herein is not intended as diagnosis, treatment or a cure. Should you have a medical condition please seek the advice of your medical doctor.