A decrease in melatonin causes increased night-time sympathetic activity, which in turn is linked to coronary disease. One study found that patients with coronary heart disease had nocturnal melatonin levels five times lower than in healthy controls. Investigators surmised that lower levels of melatonin may act to increase circulating epinephrine and norepinephrine. Atherogenic uptake of LDL cholesterol is accelerated by these hormones at high concentrations.1

Laboratory research has shown that melatonin treatment also exerts the beneficial effect of increasing the HDL/LDL ratio, possibly by enhancing the body's cholesterol clearance mechanisms.2 In addition, melatonin appears to inhibit platelet aggregation (blood clotting), which plays a significant role in the progression of cardiovascular disease.3

A non-invasive salivary test, the Comprehensive Melatonin Profile measures the circadian rhythm of melatonin secretion over a complete light-dark cycle, and is particularly recommended for patients who exhibit insomnia as part of their overall clinical condition.

References:
1 Brugger P, Marktl W, Herold M. Impaired nocturnal secretion of melatonin in coronary heart disease. Lancet 1995;345: 1408.
2 Chan TY, Tang PL. Effect of melatonin on the maintenance of cholesterol homeostasis in the rat. Endocr Res 21(3):1995:681-96.
3 Cardinali DP, Del Har MM, Vacas MI. The effects of melatonin in human platelets. Acta Physiol Pharmacol Ther Latinaom 1993;43: 1-13.

Call to set up a nutritional consultation so that tests can be performed and a comprehensive strategy of lifestyle, dietary modification and nutrient supplementation can be implemented to aid you in reversing this disorder.

For an appointment, contact our office at: 800-956-7083 and visit our web site www.completehealthinstitute.com go to lab tests and click on appropriate test for information.

Dr. Rispoli, Ph.D., L Ac. has had a clinical practice for over 20 years. Her programs work because she is so thorough in testing and providing a nutritional approach. Remember that the body can heal itself if given the proper nutrients.

The information herein is not intended as diagnosis, treatment or a cure. Should you have a medical condition please seek the advice of your medical doctor.