The brain requires a constant supply of glucose to maintain proper function. In fact, if the brain is cut off from glucose for more than 10 minutes, it will go directly into a coma. Thus, changing parameters of
glucose metabolism may play an important role in affecting mood states directly related to brain function.

Patients with hypoglycemia (low blood sugar) exhibit higher depression scores in response to glucose administration than those with normal blood sugar levels.1 And researchers have found that controlling glycemic conditions in diabetes patients correlates with improved mood states, with decreased depression, tension and fatigue.2

Depression is also frequently linked with insulin resistance. Evidence suggests that insulin has the ability to move through the blood-brain barrier, where it can influence brain function by attaching to insulin
receptors on neurons. Insulin can also enhance the transport of the amino acid tryptophan, promoting increased production and activity of serotonin, sometimes called the "happy hormone" because of its key role in affecting mood states.3

The Glucose and Insulin Tolerance Test employs a glucose challenge and a blood sample to assess the relationship of insulin and glucose, providing important clues about how hypoglycemia might be contributing to depression and other mood states.

References:

1 Berlin I, Grimaldi A, Landault C, Cesselin F, Puech AJ. Suspected postprandial hypoglycemia is associated
with beta-adrenergic hypersensitivity and emotional distress. J Clin Endocrinol Metab 1994 79(5):1428-1433.

2 Van der Does FE, De Neeling JN, Snoek FJ, Kostense PJ, Grootenhuis PA, Bouter LM, Heine RJ. Symptoms and well-being in relation to glycemic control in type II
diabetes. Diabetes Care 1996;19(3):204-210.

3 McCarty MF. Enhancing central and peripheral insulin activity as a strategy for the treatment of endogenous
depression--an adjuvant role for chromium picolinate? Med Hypotheses 1994;43(4):247 252.

Call to set up a nutritional consultation so that tests can be performed and a comprehensive strategy of lifestyle, dietary modification and nutrient supplementation can be implemented to aid you in reversing this disorder.

For an appointment, contact our office at: 800-956-7083 and visit our web site www.completehealthinstitute.com go to lab tests and click on appropriate test for information.

Dr. Rispoli, Ph.D., L Ac. has had a clinical practice for over 20 years. Her programs work because she is so thorough in testing and providing a nutritional approach. Remember that the body can heal itself if given the proper nutrients.

The information herein is not intended as diagnosis, treatment or a cure. Should you have a medical condition please seek the advice of your medical doctor.