Attention deficit disorder (ADD) and attention deficit hyperactivity disorder (ADHD) are often linked with neurotransmitter dysfunctions of the central nervous system.1-3 Serotonin, a chemical relaxant produced from the amino acid tryptophan, is normally present in high amounts in these areas. Research has shown, however, that children with ADD and ADHD often show deficiencies of plasma serotonin and tryptophan.4-6 Additionally, the development of attention deficit disorder is linked to the amino acid tyrosine, which can influence levels of dopamine and norepinephrine--other key neurochemicals involved in the brain's excitant/relaxant responses.7

In comparison with other children, children with attention deficits may exhibit deficiencies in a wide range of amino acids including phenylalanine, tyrosine, tryptophan, histidine, and isoleucine.8 A variety of alternative treatment methods can be used to treat these imbalances. Researchers suggest that even subtle changes in diet can affect amino acids levels and thereby modulate neurochemical brain function.9 A promising study in China found that treatment with a natural herbal remedy increases levels of the amino acid creatinine and other important neurochemicals, reducing symptoms of hyperkinesia and improving performance in school.10

The HPA PROFILE : Provides measurement of 6 primary urinary neurotransmitters: Serotonin, GABA, Glutamate, Dopamine, Norepinephrine, Epinephrine. Salivary Adrenal Hormones are also measured: 4 timed Cortisols and 2 DHEAs.

This profile assesses the six neurotransmitters that affect the hypothalamic-pituitary axis (HP) as well as the adrenal hormones cortisol and DHEA. Since the HPA axis initiates an adrenal response, this profile allows the practitioner to assess that response and make therapeutic decisions based on the information. Neurotransmitters are measured from a single urine sample, while cortisol (X4) and DHEA (X2) are measured from four saliva samples, the first taken between 7:00 and 8:00 am and then one every five hours thereafter for the remaining three samples.

Once tested Dr Rispoli can provide a custom amino acid program designed to balance the brain chemistry naturally, bringing a sense of calmness, focus and improved mood.

References:

1 Raskin LA, Shaywitz SE, Shaywitz BA, Anderson GM, Cohen DJ. Neurochemical correlates of attention deficit disorder. Pediatr Clin North Am 1984;31(2):387-96.

2 Malone MA, Kershner JR, Swanson JM. Hemispheric processing and methylpehidate effects in attention-deficit hyperactivity disorder J Child Neurol 1994;9(2):181-9.

3 Hunt RD, Cohen DJ, Shaywitz SE, Shaywitz BA. Strategies for study of the neurochemistry of attention deficit disorder in children. Schizophr Bull 1982;8(2):236-52.

4 Irwin M, Belendiuk K, McCloskey K, Freedman DX. Tryptophan metabolism in children with attentional deficit disorder. Am J Psychiatry 1981;138(8):1082-5.

5 Comings DE. Serotonin and the biochemical genetics of alcoholism: lessons from studies of attention deficit hyperactivity disorder (ADHD) and Tourette syndrome. Alcohol Alchol Suppl 1993;2:237-41.

6 Comings DE. Blood serotonin and tryptophan in Tourette syndrome. Am J Med Genet 1990;36(4):418-30.

7 McConnell H. Catecholamine metabolism in the attention deficit disorder: implications for the use of amino acid precursor therapy. Med Hypotheses 1985;17(4):305-11.

8 Bornstein RA, Baker GB, Carroll A, King G, Wong JT, Douglass AB. Plasma amino acids in attention deficit disorder. Psychiatry Res 1990;33(3):301-6.

9 Zeisel SH. Dietary influences on neurotransmission. Adv Pediatr 1986;33:23-47.

10 Sun Y, Wan Y, Qu X, Wang J, Fang J, Zhang L. Clinical observation and treatment of hyperkinesia in children by traditional Chinese medicine. J Tradit Chin Med 1994;14(2):105-9.

Call to set up a nutritional consultation so that tests can be performed and a comprehensive strategy of lifestyle, dietary modification and nutrient supplementation can be implemented to aid you in reversing this disorder.

For an appointment, contact our office at: 800-956-7083 and go to lab tests and click on appropriate test for information.

Dr. Rispoli, Ph.D., L Ac. has had a clinical practice for over 25 years. Her programs work because she is so thorough in testing and providing a nutritional approach. Remember that the body can heal itself if given the proper nutrients.

The information herein is not intended as diagnosis, treatment or a cure. Should you have a medical condition please seek the advice of your medical doctor.